Disorders

An increasing number of researches and studies show that cannabinoids (hereafter cited with the collective term CBD) have positive effects on a wide range of conditions and diseases. But because CBD isn’t a registered medicine, it has to be considered as a foodsupplement. However, the results are so positive and convincing that the medical effectiveness of CBD can’t be denied anymore. On this page you can read all about CBD.

On this page we have compiled an alphabetical summary of conditions with links to studies in which the effects of CBD have been researched. The majority of the studies are published by the American governmental institutions NIH (National Institutes of Health), NLM (National Library of Medicine) en NCIB (National Center for Biotechnology Information). The website Cannabinoid Medicines also contains lots of additional scientific information.

Important to know

The endocannabinoid system

The endocannabinoid system (ECS) is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors. Known as “the body’s own cannabinoid system”, the ECS is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory, and in mediating the psychoactive effects of cannabis.

Two primary endocannabinoid receptors have been identified: CB1 and CB2. CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule), Anandamide, as well as its mimetic phytocannabinoid, THC. One other main endocannabinoid is 2-Arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD. 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management

The studies

Although there already is quite a lot known about the effects of CBD, research is still in its infancy. Many of the studies below are orientating, documentary or pre-clinical.

About this page

The information on this page is not intended to diagnost, treat, cure or prevent diseases. We don’t make medical statements, but only refer to relevant studies.


Disorders

Acne

Acne vulgaris (or simply acne) is a long-term skin disease that occurs when hair follicles become clogged with dead skin cells and oil from the skin. Acne is characterized by areas of blackheads, whiteheads, pimples, and greasy skin, and may result in scarring

Results summary
Shown is that CBD has a restorative effect on the body’s own endocannabinoid system (ECS) of the skin. The ECS manages a good and balanced growth, as well as the immunocompetence and tolerance of skin cells.

Addiction

Addiction is a medical condition characterized by compulsive engagement in rewarding stimuli, despite adverse consequences.

Results summary
CBD contains several characteristics which are available to treat addiction disorders.

Alzheimer’s disease

Alzheimer’s disease (AD), also known as just Alzheimer’s, is a chronic neurodegenerative disease that usually starts slowly and gets worse over time. The disease is named after Alois Alzheimer, a German psychiatrist and neuropathologist.

Results summary
Studies conclude that the non-psychoactive receptors play a role in the disease and cannabinoids are able to support decelerate the neurodegenerative process.

Anxiety

Anxiety disorders are a group of mental disorders characterized by feelings of anxiety and fear. Anxiety is a worry about future events and fear is a reaction to current events. These feelings may cause physical symptoms, such as a fast heart rate and shakiness.

Results summary
The results suggest that CBD reduces anxieties and that this relates to the effects on the activity in limbic and paralimbic areas in the brain.

Arthritis

Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In some types other organs are also affected.

Results summary
Gathered data shows that CBD offers a therapeutic potency for relief on arthritis related pains and inflammations without detectable side effects.

Asthma

Asthma is a common long term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath.

Results summary
Several studies show that treatment with non-psychoactive cannabinoids can be a good therapeutic supplementation to the common treatment of asthma.

Autism

Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and non-verbal communication, and restricted and repetitive behavior.

Results summary
Studies demonstrate that cannabinoids can have a positive influence on the effects of autism.

Bowel disorder

Examples of bowel disorders are: Spastisch colon, Inflammatory Bowel Disease (IBD) and constipation.

Results summary
The results indicate that CBD unravels a new therapeutic strategy to treat bowel disorders.

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Not all tumors are cancerous; benign tumors do not spread to other parts of the body.

Results summary
Collectively, the non-psychoactive plant-derived cannabinoid CBD exhibits pro-apoptotic and anti-proliferative actions in different types of tumours and may also exert anti-migratory, anti-invasive, anti-metastatic and perhaps anti-angiogenic properties. On the basis of these results, evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread.

Cardiovascular disease

Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. Cardiovascular disease includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack).

Results summary
CBD positively affects arrhythmia and also to strengthens the cardiovascular system.

Chronic Pain

Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain is sometimes determined by an arbitrary interval of time since onset. Some common examples are: chronic back pain, chronic headache, phantom pain, oncological pain and fibromyalgy.

Results summary
Discovered is that persons who used cannabis experienced a substantial pain decrease, compared to persons who used a placebo. They also discovered that there were no side effects. Summarized it seems that cannabinoids are an effective and safe treatment for pain.

Crohn’s disease

Crohn’s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus. Signs and symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, and weight loss.

Results summary
Cannabis proved to reduce the medical complaints of Chron’s disease significantly.

Depression

Depression is a state of low mood and aversion to activity or apathy that can affect a person’s thoughts, behavior, feelings and sense of well-being.

Results summary
The general conclusion is that CBD possesses anti-depressive effects and therefore is a promissing materia in the fight against depression.

Diabetes

Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. Symptoms of high blood sugar include frequent urination, increased thirst, and increased hunger. If left untreated, diabetes can cause many complications.

Results summary
Results indicate that CBD can inhibit and delay destructive insulitis.

Eczema

Eczema, also known as dermatitis, is a group of diseases that results in inflammation of the skin. These diseases are characterized by itchiness, red skin, and a rash. In cases of short duration there may be small blisters while in long term cases the skin may become thickened. The area of skin involved can vary from small to the entire body.

Results summary
It is envisaged that the targeted manipulation of the ECS (aiming to normalize the unwanted skin cell growth, sebum production and skin inflammation) might be beneficial in a multitude of human skin diseases.

Epilepsy

Epilepsy is a group of neurological diseases characterized by epileptic seizures. Epileptic seizures are episodes that can vary from brief and nearly undetectable to long periods of vigorous shaking. These episodes can result in physical injuries including occasionally broken bones.

Results summary
The findings suggest that CBD acts, potentially in a CB(1) receptor-independent manner, to inhibit epileptiform activity in vitro and seizure severity in vivo.

Huntington’s disease

Huntington’s disease (HD) is an inherited disorder that results in death of brain cells. The earliest symptoms are often subtle problems with mood or mental abilities. A general lack of coordination and an unsteady gait often follow. As the disease advances, uncoordinated, jerky body movements become more apparent.

Results summary
Among Cannabis compounds, cannabidiol (CBD), which lacks any unwanted psychotropic effect, may represent a very promising agent with the highest prospect for therapeutic use.

Inflammation

Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

Results summary
A large body of preclinical data on all classes of cannabinoids point to a variety of therapeutic targets for cannabinoids and important roles for the endocannabinoids in the physiology of inflammation.

Liver disease

Liver disease (also called hepatic disease) is a type of damage to or disease of the liver.

Results summary
Molecules targeting the CB(1) and CB(2) receptors may represent potential therapeutic agents for the treatment of liver diseases. At present, the CB(1) antagonists represent the most attractive pharmaceutical tool to resolve fat accumulation in patients with non-alcoholic fatty liver disease and to treat patients with cirrhosis, as they may slow the progression of fibrosis and attenuate the cardiovascular alterations associated with the advanced stage of the disease..

Migraine

Migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe. Typically, the headaches affect one half of the head, are pulsating in nature, and last from two to 72 hours.

Results summary
The available results strongly suggest that activation of ECS could represent a promising therapeutical tool for reducing both the physiological and inflammatory components of pain that are likely involved in migraine attacks.

Mood disorder

Mood disorder is a group of diagnoses in the Diagnostic and Statistical Manual of Mental Disorders (DSM) classification system where a disturbance in the person’s mood is hypothesized to be the main underlying feature.

Results summary
The results of treatment with CBD are very promissing en show the need for further systematical research.

Multiple Sclerosis

Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to communicate, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems.

Results summary
It is discovered that cannabinoids reduce the number and intensity of spastic and ataxic symptoms.

Nausea

Nausea is a sensation of unease and discomfort in the upper stomach with an involuntary urge to vomit. It may precede vomiting, but a person can have nausea without vomiting. When prolonged, it is a debilitating symptom.

Results summary
CBD possesses anti-nausea and anti-vomiting effects by activating specific autoreceptors in the brainstem.

Neuropathic Pain

Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous system. Neuropathic pain may be associated with abnormal sensations called dysesthesia or pain from normally non-painful stimuli.

Results summary
The results indicate a potential for therapeutic use of cannabidiol in chronic painful states.

Obesity

Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.

Results summary
Cannabidiol reduced food intake in line with some existing reports, supporting the need for further mechanistic and behavioral work examining possible anti-obesity effects of cannabidiol.

Osteoporosis

Osteoporosis is a disease where decreased bone strength increases the risk of a broken bone.

Results summary
The role of cannabinoid receptors on osteoblast activity and bone formation is interesting and suggests that endocannabinoids possess bone anabolic capabilities.

Parkinson’s disease

Parkinson’s disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking.

Results summary
The findings point to a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities.

Psoriasis

Psoriasis is a long-lasting autoimmune disease which is characterized by patches of abnormal skin. These skin patches are typically red, itchy, and scaly. They may vary in severity from small and localized to complete body coverage.

Results summary
Shown is that CBD has a restorative effect on the body’s own endocannabinoid system (ECS) of the skin. The ECS manages a good and balanced growth, as well as the immunocompetence and tolerance of skin cells.

Rheumatism

Rheumatism or rheumatic disorder is an umbrella term for conditions causing chronic, often intermittent pain affecting the joints and/or connective tissue. The study of, and therapeutic interventions in, such disorders is called rheumatology.

Schizophrenia

Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand what is real. Common symptoms include false beliefs, unclear or confused thinking, hearing voices, reduced social engagement and emotional expression, and a lack of motivation.

Results summary
CBD can be a safe and well-tolerated alternative treatment for schizophrenia.

Sleep disorder

A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. Some sleep disorders are serious enough to interfere with normal physical, mental, social and emotional functioning.

Results summary
The systemic acute administration of CBD appears to increase total sleep time.

Stress

In psychology, stress is a feeling of strain and pressure. Small amounts of stress may be desired, beneficial, and even healthy. Excessive amounts of stress, however, may lead to bodily harm. Stress can increase the risk of strokes, heart attacks, ulcers, dwarfism, and mental illnesses such as depression.

Results summary
The endocannabinoid system is affected by and can oppose the effects of prolonged stress and, as such, represents a potential target for the development of novel antidepressant agents.